The aim of this research work is to reduce the frequency of dosing, decreasing the required dose employed, providing uniform drug delivery, reduction of side effects and enhancement of patient compliance of antihypertensive drug. Captopril was choosen as a model drug because of its higher water solubility. From the results obtained, the hydrophilic polymer xanthan gum and chitosan used individually could not sufficiently produce controlled release so must be combined in various ratios for effective oral controlled release to be achieved of multilayer matrix tablet that complied with all parameters. This study is carried out to design controlled release multilayered matrix tablets of antihypertensive drug. This book is a good guide for students who want to learn about formulation technology of multilayer matrix tablets along with... The purpose of study to formulate and evaluate multi-layer matrix tablets using hydrophilic polymer, namely xanthan gum and chitosan by the wet granulation.